Usual Adult Dose for Megaloblastic Anemia
1 mg orally, intramuscularly, subcutaneously or IV once a day. May continue until clinical symptoms of folate deficiency and the hematological profile have normalized.
Usual Adult Dose for Folic Acid (B COLEX) Deficiency
400 to 800 mcg orally, intramuscularly, subcutaneously or IV once a day.
Women of childbearing age, pregnant, and lactating women: 800 mcg orally, intramuscularly, subcutaneously or IV once a day.
Usual Pediatric Dose for Folic Acid (B COLEX) Deficiency
Infant:
0.1 mg orally, intramuscularly, subcutaneously or IV once a day.
Less than 4 years: up to 0.3 mg orally, intramuscularly, subcutaneously or IV once a day.
4 years or older: 0.4 mg orally, intramuscularly, subcutaneously or IV once a day.
Usual Pediatric Dose for Vitamin/Mineral Supplementation
Recommended daily allowance (RDA):
Premature neonates: 50 mcg/day (15 mcg/kg/day).
Full-term neonates and infants 1 to 6 months: 25 to 35 mcg/day.
1 to 3 years: 150 mcg/day.
4 to 8 years: 200 mcg/day.
9 to 13 years: 300 mcg/day.
14 years and older: 400 mcg/day.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Dose Adjustments
Rarely, a dosage of 2 mg/day may be required, particularly in patients with malabsorption, alcoholism, chronic hemolysis, chronic exfoliative skin disease or who are on concomitant anticonvulsant therapy.
Dialysis
Folic Acid (B COLEX) is removed by both hemodialysis and peritoneal dialysis. The amount removed varies with type equipment used.
Because folate may accumulate in patients with end-stage renal disease, side effects may be more likely in this patient who is undergoing dialysis. Once this patient's body stores of folate are replete, three times a week dosing may be just as beneficial as once daily dosing but should portend a lower risk of side effects.
Other Comments
The recommended daily allowance of Folic Acid (B COLEX) for adult males and females ranges from 150 to 200 and 150 to 180 mcg/day, respectively.
There is a potential danger in administering Folic Acid (B COLEX) to patients with undiagnosed anemia, since Folic Acid (B COLEX) may obscure the diagnosis of pernicious anemia by alleviating the hematologic manifestations of the disease while allowing the neurologic complications to progress.
Severe megaloblastic anemia may require therapy for 4 to 5 weeks. Once stabilized, if dietary intake is inadequate, maintenance therapy can be started.
Applies to the following strengths: 100 mg; 500 mg
Usual Adult Dose for:
- Niacin Deficiency
- Pemphigus
Usual Pediatric Dose for:
- Niacin Deficiency
- Pemphigus
Additional dosage information:
- Renal Dose Adjustments
- Liver Dose Adjustments
- Dialysis
- Other Comments
Usual Adult Dose for Niacin Deficiency
Recommended Daily Allowances (RDA):
Males: 19 mg orally each day
Females: 13 mg orally each day
Initial dose: 100 mg orally 3 times a day, with or after meals
Maintenance dose: 100 to 500 mg orally up to 3 times a day, with or after meals
Niacinamide (B COLEX) has toxic potential at adult doses in excess of 3 g/day.
Niacinamide (B COLEX) may also be administered parenterally as a component of injectable multivitamin additives contained in parenteral nutrition products. All existing parenteral vitamin products for adults contain 40 mg/vial, which is the dose recommended by the American Medical Association/Nutrition Advisory Group for patients 11 years and older requiring parenteral vitamins.
Usual Adult Dose for Pemphigus
Recommended Daily Allowances (RDA):
Males: 19 mg orally each day
Females: 13 mg orally each day
Initial dose: 100 mg orally 3 times a day, with or after meals
Maintenance dose: 100 to 500 mg orally up to 3 times a day, with or after meals
Niacinamide (B COLEX) has toxic potential at adult doses in excess of 3 g/day.
Niacinamide (B COLEX) may also be administered parenterally as a component of injectable multivitamin additives contained in parenteral nutrition products. All existing parenteral vitamin products for adults contain 40 mg/vial, which is the dose recommended by the American Medical Association/Nutrition Advisory Group for patients 11 years and older requiring parenteral vitamins.
Usual Pediatric Dose for Niacin Deficiency
Recommended Daily Allowances (RDA):
0 to 6 months: 5 mg orally each day
6 months to 1 year: 6 mg orally each day
1 to 3 years: 9 mg orally each day
4 to 6 years: 12 mg orally each day
7 to 10 years: 13 mg orally each day
Males:
11 to 14 years: 17 mg orally each day
15 to 18 years: 20 mg orally each day
19 to 50 years: 19 mg orally each day
Females:
11 to 50 years: 13 mg orally each day
Niacinamide (B COLEX) may also be administered parenterally as a component of injectable multivitamin additives contained in parenteral nutrition products. All existing parenteral vitamin products for children contain 17 mg/vial, which is the dose recommended by the American Medical Association/Nutrition Advisory Group for patients under 11 years of age.
Usual Pediatric Dose for Pemphigus
Recommended Daily Allowances (RDA):
0 to 6 months: 5 mg orally each day
6 months to 1 year: 6 mg orally each day
1 to 3 years: 9 mg orally each day
4 to 6 years: 12 mg orally each day
7 to 10 years: 13 mg orally each day
Males:
11 to 14 years: 17 mg orally each day
15 to 18 years: 20 mg orally each day
19 to 50 years: 19 mg orally each day
Females:
11 to 50 years: 13 mg orally each day
Niacinamide (B COLEX) may also be administered parenterally as a component of injectable multivitamin additives contained in parenteral nutrition products. All existing parenteral vitamin products for children contain 17 mg/vial, which is the dose recommended by the American Medical Association/Nutrition Advisory Group for patients under 11 years of age.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Because Niacinamide (B COLEX) is primarily metabolized by the liver and because of the risk of hepatotoxicity, Niacinamide (B COLEX) in not recommended in patients with liver dysfunction.
Dialysis
Data not available
Other Comments
Taking Niacinamide (B COLEX) with food may reduce stomach upset.
Niacinamide (B COLEX) should not be taken with hot drinks.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circ*mstances.
Medical Disclaimer
More about Niacinamide (B COLEX)
- Niacinamide (B COLEX) Side Effects
- During Pregnancy
- Drug Interactions
- Support Group
- 1 Review
- Drug class: vitamins
Consumer resources
- Niacinamide (B COLEX)
- Niacinamide (B COLEX) Extended-Release Tablets
Related treatment guides
- Niacin Deficiency
- Pemphigus
